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KMID : 0043319980210050591
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Archives of Pharmacal Research
1998 Volume.21 No. 5 p.591 ~ p.594
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Structural Analogues of Cumambrin B from the Flower of Chrysanthemum boreale
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Jang Dae-Sik
Yang Min-Suk
Ha Tae-Jung
Park Ki-Hun
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Abstract
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The structural analogues of cumambrin B(1, 2, 3, 4) were isolated from the flower of Chrysnathemum boreale Makino. The structures of compounds were determined by two-dimensional COSY and COSY spectra with the aid of homonuclear and heteronuclear double resonance experiment. The stereochemistry of compounds has been verified from single crystal X-ray diffraction of cumambrin A(2). the antimicrobial activities of these guaianolides have been studied.
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KEYWORD
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Chrysanthemum boreale, Cumambrin A, Cumambrin B, Angeloylcumambrin B, Tigloylcumambrin B, Guaianolide, Antimicrobial activity
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